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KMID : 0903520080510040316
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Journal of the Korean Society of Agricultural Chemistry and Biotechnology
2008 Volume.51 No. 4 p.316 ~ p.320
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Constituents of the seeds of Cornus officinalis with Inhibitory Activity on the Formation of Advanced Glycation End Products (AGEs)
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Lee Ga-Young
Jang Dae-Sik
Lee Yun-Mi
Kim Young-Sook
Kim Jin-Sook
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Abstract
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Ten compounds, (+)-pinoresinol (1), (?)-balanophonin (2), gallicin (3), vanillin (4), 4-hydroxybenzaldehyde (5), coniferaldehyde (6), betulinic acid (7), ursolic acid (8), 5-hydroxymethyl furfural (9), and malic acid (10), were isolated from a EtOAc-soluble fraction of the seeds of Cornus officinalis. The structures of these compounds were elucidated by spectroscopic methods as well as by comparison with reported values. Compounds 1, 2, and 4-7 were isolated from this species for the first time. All the isolates (1-10) were subjected to an in vitro bioassay to evaluate their inhibitory activity against advanced glycation end products (AGEs) formation. Among these, compounds 2 and 3 showed the significant inhibitory activity on AGEs formation with IC50 values of 27.81 and 18.04 μM, respectively.
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KEYWORD
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advanced glycation end products (AGEs), (-)-balanophonin, Cornaceae, Cornus officinalis, diabetic complications, gallicin
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